منابع مشابه
Cytoskeleton of apicomplexan parasites.
The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp., the cause of malaria; Toxoplasma gondii and Cryptosporidium parvum, opportunistic pathogens of immunocompromised individuals; and Eimeria spp. and Theileria spp., parasites of considerable agricultural importance. These protozoan parasites share distinctive morphological features, cytoskeletal or...
متن کاملAcidocalcisomes in Apicomplexan parasites.
Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to man. They posses an acidic matrix that contains several cations bound to phosphates, mainly present in the form of short and long polyphosphate chains. Their matrix is acidified through the action of proton pumps such as a vacuolar proton ATPase and a vacuolar proton pyrophosphatase. The calci...
متن کاملInsP3 Signaling in Apicomplexan Parasites
BACKGROUND Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell functions. Specifically, the ability to generate myo-inositol 1,4,5-trisphosphate (InsP3) via phospholipase C (PLC) dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to InsP3 and diacylglycerol (DAG) initiates i...
متن کاملATG8 localization in apicomplexan parasites
Macroautophagy (hereafter referred to as autophagy) is a major intracellular degradation system that, in eukaryotes, is mediated by a special organelle, the autophagosome. Upon autophagy induction, small pieces of the cytoplasm are enclosed by phagophores, which mature into autophagosomes. Then, completed autophagosomes fuse with the lysosome, and the cytoplasm-derived materials inside the auto...
متن کامل1 The kinomes of apicomplexan parasites
Protein phosphorylation plays a fundamental role in the biology and invasion strategies of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis ...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 2002
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.66.1.21-38.2002